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Dosage and Administration
Administration steps of Fentanyl Patch
Choose a suitable site such as a dry, flat surface of non-irradiated and non-irritated skin for patch application. Commonly used sites include the chest and upper arm. Gently cleansing with clean water. Avoid using any soap or alcohol as these may result in skin irritation. Clipping off any hair if present, with scissors. Avoid using a shaver as this may result in skin irritation. Tear along the pre-cut edge to remove the patch. To avoid accidentally cutting the patch, do not use scissors to cut open the packet. Peel off one side of the plastic backing first, taking care not to touch the adhesive. Apply the adhesive to the application site. After the first half of the patch has been applied, remove the other plastic backing and smoothen out the patch onto the skin. Ensure that there are no air bubbles present.
Press the patch firmly in place with the palm of your hand and hold for about 30 seconds to ensure good adherence to the skin. If adhesion of patch to skin is a problem, use an adhesive film dressing over the patch. Remove the patch after 72 hours and apply a new patch to a different area of the skin.
Dosage and Administration
Dosage Forms & Strengths
Transdermal patch: 12mcg/hour, 25mcg/hour, 37.5 mcg/hour, 50mcg/hour, 75mcg/hour and 100mcg/hour.
Transdermal fentanyl comes as a patch to apply to the skin. The patch is usually applied to the skin once every 72 hours. Change your patch at about the same time of day every time you change it.
Transdermal fentanyl is indicated for chronic pain in opioid-tolerant patients, severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate. Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals. Individualize dosing based on the severity of pain, patient response, prior analgesic experience, and risk factors for addiction, abuse, and
misuse. Each transdermal system is intended to be worn for 72 hours. Mild to moderate hepatic and renal impairment: Initiate treatment with one half the usual starting dose.
Duragesic (Transdermal Duragesic) should only be used in patients who are already receiving opioid therapy, who have demonstrated opioid tolerance, and who require a total daily dose at least equivalent to Duragesic 25 mcg/h. Patients who are considered opioid-tolerant are those who have been taking, for a week or longer, at least 60 mg of morphine daily, or at least 30 mg of oral oxycodone daily, or at least 8 mg of oral hydromorphone daily or an equianalgesic dose of another opioid. Take the bold step now and Buy Duragesic Patch Online with us. Buy Pain Pills Online . Kjøp Fentanyl Patch Online
Fentanyl patches may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Nausea, fatigue, Confusion, vomiting, constipation, Constricted pupils, lightheadedness, dizziness, Trouble concentrating, drowsiness, or headache may occur. Mild irritation, Sweating, itching, swelling of the face, upper stomach pain, throat, or tongue, bloating or swelling of the face, arms, hands, lower legs, or feet, tremor, unusual weight gain or loss or redness at the application site may also occur. Some of these side effects may decrease after you have been using this medication for a while. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Headache, mood changes, feeling cold, drowsiness, depression, difficulty falling asleep or staying asleep
uncontrollable shaking of a part of the body, pain, burning, tingling, or numbness in the hands or feet,
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Because serious or life-threatening hypo ventilation could occur, DURAGESIC (fentanyl transdermal patches) is contraindicated:
-In patients who are not opioid-tolerant.
-In the management of acute pain or in patients who require opioid analgesia for a
short period of time.
-In the management of post-operative pain, including use after out-patient or day
surgeries (e.g., tonsillectomies).
-In the management of mild pain.
-In the management of intermittent pain [e.g. use on an as needed basis (prn)].
Do not use this medication if you:
-are allergic to fentanyl, the adhesives used in the patch, or any ingredients of the medication
-are not already using opioid (narcotic) painkillers to manage your pain
-have acute or severe bronchial asthma
-have severe difficulty breathing
-have delirium tremens (e.g., confusion, diarrhea, shaking, fever, hallucinations, disorientation) associated with alcohol withdrawal
-have acute alcoholism
-have epilepsy and other conditions that can cause seizures
-have increased intracranial pressure (increased pressure inside the head), cerebrospinal pressure (increased pressure inside the head and spine), or head injury
-are pregnant, in labour or delivering, or breastfeeding
WARNINGS AND PRECAUTIONS
Fentanyl can slow or stop your breathing, and may be habit-forming. Misuse of Fentanyl or overdose may cause OR Death, especially in a child or other person using the medicine without a prescription. Using this medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn. Fatal side effects can occur if you use this medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.
Since the peak fentanyl levels occur between 24 and 72 hours of treatment, prescribers should be aware that serious or life threatening hypoventilation may occur, even in opioid tolerant patients, during the initial application period.
Precautions must also be taken in patients with the following conditions;
• Respiratory impairment
• Increased intracranial pressure
• Hepatic impairment.
The concomitant use of Duragesic with potent cytochrome P450 3A4 inhibitors(ritonavir, ketoconazole, itraconazole, troleandomycin, clarithromycin, nelfinavir, and nefazodone) may result in an increase in fentanyl plasma concentrations, which could increase or prolong adverse drug effects and may cause potentially fatal respiratory depression. Patients receiving Duragesic and potent CYP3A4 inhibitors should be carefully monitored for an extended period of time and dosage adjustments should be made if warranted. see wiki