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Buprenorphine hydrochloride is a white powder, weakly acidic with limited solubility in water. Chemically, it is 21- Cyclopropyl-7a-[(S) -1- hydroxy-1, 2, 2 -trimethylpropyl]-6, 14-endo-ethano-6, 7, 8, 14-tetrahydrooripavine hydrochloride.
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Suboxone Strips Uses
Suboxone Sublingual Film is used as part of a medical, social and psychological treatment program for patients dependent on opioids like heroin, morphine, oxycodone or codeine. Suboxone Sublingual Film is used to help such patients to regain control over their lives.
The most common way to administer Suboxone is through Suboxone strips. Sometimes called Suboxone film, the strip (or film) is administered sublingually, which means put under the tongue and left to dissolve.
The film should not be cut, chewed or swallowed.
Sometimes Suboxone strips are placed on the inside of the left or right cheek. There, it is left to dissolve in the same manner as under the tongue.
In both cases, the strip has to be thoroughly dissolved or the drug may not have its required effect.
Suboxone Sublingual Film is indicated for the treatment of opiate dependence within a framework of medical, social and psychological treatment.
DOSAGE AND ADMINISTRATION
Treatment with Suboxone Sublingual Film is intended for adults and children aged 16 years or over who have agreed to be treated for addiction. When initiating buprenorphine treatment, the physician should be aware that it can precipitate withdrawal in opioid-dependent patients if given too soon after the administration of heroin, methadone or another opiate.
The route of administration of Suboxone Sublingual Film is sublingual. Suboxone Sublingual Film should not be swallowed whole as this reduces the bioavailability of the medicine. It should be noted that the sublingual route is the only effective and safe route of administration for this medicine.
Method of Administration
Place Suboxone Sublingual Film under the tongue. If an additional Suboxone Sublingual Film is necessary to achieve the prescribed dose, place it sublingually on the opposite side from the first film, and in a manner to minimise overlapping as much as possible. If more than two films are required, place the next film or films after the first two have dissolved. The soluble film must be kept under the tongue until it is completely dissolved, which takes on average between 4 and 8 minutes. No food or drink should be consumed until the film is completely dissolved. Suboxone Sublingual Film should not be chewed, swallowed, or moved from placement.
Suboxone Sublingual Film Side Effects
Mouth numbness, mouth redness, mouth pain, headache, dizziness, numbness
or tingling, drowsiness, sleep problems (insomnia), stomach pain, constipation,
feeling drunk, or trouble concentrating.
Suddenly stopping use of Suboxone can elicit unpleasant withdrawal symptoms.
Side effects that may occur during a period of active use include:
Nausea and vomiting
Get medical help right away if these side effects persist.
-Hypersensitivity to buprenorphine or naloxone or any other component of the soluble film.
-Children less than 16 years of age.
-Severe respiratory or hepatic insufficiency.
-Acute intoxication with alcohol or other CNS depressant.
WARNINGS AND PRECAUTIONS
General: Suboxone Sublingual Film should be administered with caution in elderly or debilitated patients and those with impairment of hepatic, pulmonary, or renal function; myxoedema or hypothyroidism, adrenal cortical insufficiency (eg Addison’s disease); CNS depression or coma; toxic psychoses; prostatic hypertrophy or urethral stricture; acute alcoholism; delirium tremens; or kyphoscoliosis.
As with other opioids, caution is advised in patients using buprenorphine and having:
– hypotension, and prostatic hypertrophy and urethral stenosis.