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Buprenorphine hydrochloride is a white powder, weakly acidic with limited solubility in water. Chemically, it is 21- Cyclopropyl-7a-[(S) -1- hydroxy-1, 2, 2 -trimethylpropyl]-6, 14-endo-ethano-6, 7, 8, 14-tetrahydrooripavine hydrochloride. Buy Suboxone Strips online
Naloxone hydrochloride is a white to slightly off-white powder that exists as the dihydrate and is soluble in water, in dilute acids and in strong alkali. Chemically, it is (-)-17-Allyl-4, 5a-epoxy-3, 14- dihydroxymorphinan-6-one hydrochloride dihydrate. Visit Wikipedia for more information. Buy Pain Pills Online
Suboxone Sublingual film is a new formulation of Suboxone with the same active ingredients and doses as the tablets (buprenorphine and naloxone in 2/0.5mg and 8/2mg preparations). They are packaged in individual sachets in boxes of 28. The films are orange with the strength printed in white (N2 or N8), and have a lime flavor, often preferred to the lemon-lime flavor of the tablets. Suboxone Film will make supervised dosing easier by reducing the time required for effective supervision. Whereas Suboxone tablets and Subutex tablets require 3 to 10 minutes to dissolve, Suboxone Sublingual film adheres within seconds to the oral mucosa and is difficult to remove after 30 to 60 seconds. Suboxone Sublingual film is indicated for maintenance treatment of opioid dependence as part of a complete treatment plan to include counseling and psychosocial support. Advise client not to eat immediately before dosing, as it may interfere with absorption. Offer a sip of water to moisten mouth. Ensure hands are clean and dry as the film may stick to wet hands and make it difficult to place them correctly in the mouth. Before taking Suboxone Sublingual film, it’s a good idea to drink some water to moisten your mouth. This should help the film(s) dissolve more easily. Make sure your hands are dry. SUBOXONE Film should be held between 2 fingers by the outside edges of the film. Suboxone Sublingual film should be placed under your tongue (close to the base on either side). The medication in Suboxone Sublingual film is absorbed into the bloodstream through blood vessels under your tongue. Suboxone Sublingual film is administered sublingually or buccally as a single daily dose. Suboxone Sublingual film is a medication used to treat adults who are addicted to (dependent on) opioid drugs as part of a complete treatment program that also includes counseling and behavioral therapy. Suboxone Sublingual Films (buprenorphine/naloxone) is a brand-name prescription drug. It’s used to treat dependence on opioid drugs. Suboxone comes as an oral film that’s placed under your tongue (sublingual) or between your gums and cheek (buccal). The film dissolves in your mouth. Suboxone is a narcotic (also known as Buprenorphine and Naloxone) used for treating opioid dependency among patients that are addicted to narcotic substances such as Morphine, Heroine, and Codeine. Suboxone is a partial rather than full opiate that blocks opiate receptors and produces a slightly less euphoric effect than other known opiates.
Suboxone contains two drugs in each film: buprenorphine and naloxone. It’s available in four strengths:
2 mg buprenorphine / 0.5 mg naloxone
4 mg buprenorphine / 1 mg naloxone
8 mg buprenorphine / 2 mg naloxone
12 mg buprenorphine / 3 mg naloxone
Suboxone is an opioid. Suboxone is approved to treat opioid dependence. Suboxone can also be habit-forming and may lead to addiction and dependence. It must be used carefully.
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Suboxone Strips Uses
Suboxone Sublingual Film is used as part of a medical, social and psychological treatment program for patients dependent on opioids like heroin, morphine, oxycodone or codeine. Suboxone Sublingual Film is used to help such patients to regain control over their lives.
The most common way to administer Suboxone is through Suboxone strips. Sometimes called Suboxone film, the strip (or film) is administered sublingually, which means put under the tongue and left to dissolve.
The film should not be cut, chewed or swallowed.
Sometimes Suboxone strips are placed on the inside of the left or right cheek. There, it is left to dissolve in the same manner as under the tongue.
In both cases, the strip has to be thoroughly dissolved or the drug may not have its required effect.
Suboxone Sublingual Film is indicated for the treatment of opiate dependence within a framework of medical, social and psychological treatment.
The first dose of buprenorphine/naloxone should be started only when objective signs of moderate withdrawal appear.
On Day 1, give an induction dosage of up to 8 mg/2 mg Suboxone Sublingual film. Clinicians should start with an initial dose of 2 mg/0.5 mg or 4 mg/1 mg buprenorphine/naloxone and may titrate upwards in 2 or 4 mg increments of buprenorphine, at approximately 2-hour intervals, under supervision, to 8 mg/2 mg buprenorphine/naloxone based on the control of acute withdrawal symptoms.
The first dose of SUBOXONE sublingual film or buprenorphine should be administered when signs of moderate opioid withdrawal appear, and not less than 6 hours after the patient last used an opioid.
On Day 2, a single daily dose of up to 16 mg/4 mg Suboxone Sublingual film is recommended.
Place Suboxone sublingual film under the tongue and keep it there until completely dissolved. Do not swallow, chew or move the film after it is placed under the tongue, as doing any of these makes the medicine less effective.
For maintenance, Suboxone Sublingual film may be administered buccally or sublingually. The dosage of Suboxone Sublingual film from Day 3 onwards should be progressively adjusted in increments/decrements of 2 mg/0.5 mg or 4 mg/1 mg buprenorphine/naloxone to a level that holds the patient in treatment and suppresses opioid withdrawal signs and symptoms. Buy Suboxone Strips online
After treatment induction and stabilization, the maintenance dose of SUBOXONE sublingual film is generally in the range of 4 mg/1 mg buprenorphine/naloxone to 24 mg/6 mg buprenorphine/naloxone per day depending on the individual patient and clinical response. The recommended target dosage of SUBOXONE sublingual film during maintenance is 16 mg/4 mg buprenorphine/naloxone/day as a single daily dose. Dosages higher than 24 mg/6 mg daily have not been demonstrated to provide a clinical advantage. Buy Suboxone Strips online
Method of Administration
Suboxone Sublingual film must be administered whole. Do not cut, chew, or swallow SUBOXONE sublingual film.
SUBOXONE SUBLINGUAL FILM contains buprenorphine hydrochloride and naloxone hydrochloride at a ratio of 4:1 buprenorphine: naloxone. Buy Suboxone Strips online
Sublingual Administration of suboxone sublingual film
Place one film under the tongue, close to the base on the left or right side. If an additional film is necessary to achieve the prescribed dose, place an additional film sublingually on the opposite side from the first film. Place the film in a manner to minimize overlapping as much as possible. The film must be kept under the tongue until the film is completely dissolved. If a third film is necessary to achieve the prescribed dose, place it under the tongue on either side after the first 2 films have dissolved. Buy Suboxone Strips online
Buccal Administration of suboxone sublingual film
Place one film on the inside of the right or left cheek. If an additional film is necessary to achieve the prescribed dose, place an additional film on the inside of the opposite cheek. The film must be kept on the inside of the cheek until the film is completely dissolved. If a third film is necessary to achieve the prescribed dose, place it on the inside of the right or left cheek after the first two films have dissolved.
SUBOXONE sublingual film should NOT be moved after placement. Proper administration technique should be demonstrated to the patient. Take suboxone sublingual film exactly as prescribed by your doctor.
Place Suboxone Sublingual Film under the tongue. If an additional Suboxone Sublingual Film is necessary to achieve the prescribed dose, place it sublingually on the opposite side from the first film, and in a manner to minimise overlapping as much as possible. If more than two films are required, place the next film or films after the first two have dissolved. The soluble film must be kept under the tongue until it is completely dissolved, which takes on average between 4 and 8 minutes. No food or drink should be consumed until the film is completely dissolved. Suboxone Sublingual Film should not be chewed, swallowed, or moved from placement.
DOSAGE AND ADMINISTRATION
Treatment with Suboxone Sublingual Film is intended for adults and children aged 16 years or over who have agreed to be treated for addiction. When initiating buprenorphine treatment, the physician should be aware that it can precipitate withdrawal in opioid-dependent patients if given too soon after the administration of heroin, methadone or another opiate.
The route of administration of Suboxone Sublingual Film is sublingual. Suboxone Sublingual Film should not be swallowed whole as this reduces the bioavailability of the medicine. It should be noted that the sublingual route is the only effective and safe route of administration for this medicine.
Suboxone Sublingual Film Side Effects
Suboxone sublingual film side effects include; sleep problems (insomnia), vomiting, constipation; nausea, headache, back pain; increased sweating; fast or pounding heartbeats, redness or numbness inside your mouth; tongue pain, dizziness, blurred vision, drowsiness, feeling drunk and trouble concentrating.
Mouth numbness, mouth redness, mouth pain, headache, dizziness, numbness
or tingling, drowsiness, sleep problems (insomnia), stomach pain, constipation,
feeling drunk, or trouble concentrating.
Suddenly stopping use of Suboxone can elicit unpleasant withdrawal symptoms.
Side effects that may occur during a period of active use include:
Nausea and vomiting
Get medical help right away if these side effects persist.
suboxone sublingual film is contraindicated to patients who show hypersensitivity to buprenorphine or naloxone or any other component of the soluble film.
suboxone sublingual film is contraindicated to Children less than 16 years of age.
suboxone sublingual film is contraindicated in patients with severe respiratory or hepatic insufficiency.
suboxone sublingual film may cause acute intoxication with alcohol or other CNS depressants.
suboxone sublingual film is contraindicated during Pregnancy and breastfeeding.
-Hypersensitivity to buprenorphine or naloxone or any other component of the soluble film.
-Children less than 16 years of age.
-Severe respiratory or hepatic insufficiency.
-Acute intoxication with alcohol or other CNS depressant.
WARNINGS AND PRECAUTIONS
Suboxone Sublingual Film can be abused in a manner similar to other opioids As such, clinical monitoring appropriate to the patient’s level of stability is essential.
Children who take Suboxone Sublingual Film can have severe, possibly fatal, respiratory depression. Keep Suboxone Sublingual Film out of the sight and reach of children.
Cytolytic hepatitis, jaundice, and allergic reactions, including anaphylactic shock, have been reported with Suboxone Sublingual Film use.
Suboxone Sublingual Film can cause serious life-threatening respiratory depression and death, particularly when taken by the intravenous (IV) route in combination with benzodiazepines o rother central nervous system (CNS) depressants such as sedatives, tranquilizers, or alcohol.
General: Suboxone Sublingual Film should be administered with caution in elderly or debilitated patients and those with impairment of hepatic, pulmonary, or renal function; myxoedema or hypothyroidism, adrenal cortical insufficiency (eg Addison’s disease); CNS depression or coma; toxic psychoses; prostatic hypertrophy or urethral stricture; acute alcoholism; delirium tremens; or kyphoscoliosis.
As with other opioids, caution is advised in patients using buprenorphine and having:
– hypotension, and prostatic hypertrophy and urethral stenosis.